That looks like a Linux reference to a serial port. Beside the USB0 port what are you trying to talk to? On the hardware side I have: USB port <——> SiLabs CP2102 device (my USB to Serial adapter) <——> Raspberry Pi UART (serial console) The Raspberry Pi only uses ground, Tx & Rx What do you have? > > I just do not know how to get the “/dev/ttyUSB0” on the Mac. > >